The Life Scientific - Edith Heard on unravelling the mystery of X-chromosome inactivation

Download Edith Heard on unravelling the mystery of X-chromosome inactivation

Imagine looking at a map of a city you thought you knew inside-out, only to discover a collection of tightly knit neighbourhoods that nobody had ever realised existed... Edith Heard has achieved something rather similar with DNA.

Edith is a leading expert in epigenetics: put simply, the science around how our bodies can turn particular genes on or off without actually altering our DNA. She’s spent her career studying the mechanisms that make us who we are and transforming our understanding of how X chromosomes are expressed; notably, how female cells turn off the spare X chromosome.

Talking to Professor Jim Al-Khalili, Edith discusses her journey from a shy and introverted youngster to the cutting edge of European science - including her latest role as Director of London’s prestigious Francis Crick Institute.

Presented by Jim Al-Khalili
Produced by Lucy Taylor
A BBC Studios production

Published on Tuesday, 13th October 2026.

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